ABSTRACT
SARS-CoV-2 responsible for Covid-19, although having a primary pulmonary tropism, also causes variable neurological damage that it is important to know. In this narrative review, after briefly recalling the particularities of SARS-CoV-2 infection in the elderly, the authors present the main hypotheses that explain the neurotropism of SARS-CoV-2, the main types of neurological damage and the possible interactions with Parkinson's disease and Alzheimer's disease. © 2022 Elsevier Masson SAS
ABSTRACT
Le SARS-CoV-2 responsable du Covid-19, bien qu’ayant un tropisme au premier plan pulmonaire, entraîne également des atteintes neurologiques diverses qu’il est important de connaître. Dans cette revue narrative, après avoir rappelé brièvement les particularités de l’infection à SARS-CoV-2 chez le sujet âgé, les auteurs présentent les hypothèses pouvant expliquer le neurotropisme du SARS-CoV-2, les principales atteintes neurologiques et les interactions possibles avec la maladie de Parkinson et la maladie d’Alzheimer.
ABSTRACT
Résumé Le SARS-CoV-2 responsable du Covid-19, bien qu'ayant un tropisme au premier plan pulmonaire, entraîne également des atteintes neurologiques diverses qu’il est important de connaître. Dans cette revue narrative, après avoir rappelé brièvement les particularités de l’infection à SARS-CoV-2 chez le sujet âgé, les auteurs présentent les hypothèses pouvant expliquer le neurotropisme du SARS-CoV-2, les principales atteintes neurologiques et les interactions possibles avec la maladie de Parkinson et la maladie d’Alzheimer. SARS-CoV-2 responsible for Covid-19, although having a primary pulmonary tropism, also causes variable neurological damage that it is important to know. In this narrative review, after briefly recalling the particularities of SARS-CoV-2 infection in the elderly, the authors present the main hypotheses that explain the neurotropism of SARS-CoV-2, the main types of neurological damage and the possible interactions with Parkinson's disease and Alzheimer's disease.
ABSTRACT
BACKGROUND: Governments around the world have imposed varied containment measures to curb the spread of the COVID-19 infection. The psychological impact could be highly negative in patients with neurologic condition like Parkinson's Disease (PD). METHODS: We prospectively evaluated symptoms of depression and anxiety in 50 (26 females; mean age at 60.4) non demented Moroccan PD patients, using Hospital Anxiety and Depression Scale (HADS), at the beginning and after 6 weeks of a full confinement. RESULTS: At the first evaluation, 28% of patients had depression while 32% had anxiety. After 6 weeks of confinement, some patients got worse and others got better scores but no significant statistical difference for both troubles was seen. CONCLUSION: Our results show that there is no significant impact of 6 weeks of confinement on overall anxiety and depression scores. However, confinement could have an unexpected positive psychological impact on a significant number of PD patients.